Currents in the Drugstore Practise and LearningAsma El-Magboub, Ian S
Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical needs and pharmacology of curcumin
Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin ‘s the big part of the fresh red dye from turmeric, an Indian liven that’s obtained from the new rhizome of one’s exotic plant Curcuma longa, which is one of the Zingiberaceae family unit members. Within part, i talk about the pharmacological activities out of curcumin and you can explore the latest unit bases for these factors. I then remark new shown and you can potential scientific spends regarding curcumin. Curcumin is known over the years as the a healing broker, however, its process off step was detailed. New pharmacological aftereffects of curcumin seem to be caused by a synergism out of systems away from weakened biochemical affairs with several physiological plans within the interrelated signaling paths. Such plans were enzymes eg cyclooxygenase, lipoxygenase and you can necessary protein kinases, and transcription factors including NF-?B, STAT and you will Nrf2. Modulation of these particles impacts downstream affectors that make the latest antiinflammatory, antioxidant, chemopreventive, anticancer, and antimicrobial items off curcumin. These effects were checked-out within the medical examples out-of curcumin to possess soreness and you will inflammatory sickness, cancer, Alzheimer situation, cardio ailment, and you will all forms of diabetes. New trials used varying doses off curcuminwith different wavelengths and you may duration, into the general completion one highest dosage regarding curcumin during the amount of grams must obtain therapeutic effects. Find out more
Curcumin: Synthesis, Emerging Role when you look at the Discomfort Management and Wellness Implications
Book Chapter Types of bush-derived pharmaceuticals having get to be the focus out of continuing and you will great look and you will invention focus enjoys, up until now, come quite scarce. Just after a long period, the last 2 decades had been described as a beneficial 100-bend escalation in what amount of medical content composed a-year that is regarding relevance on the accessibility curcumin within the biomedicine. Find out more
Construction, synthesis and you may physical circumstances from curcumin prodrugs
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some possible pharmacological effects and may provides healing apps in many state says, just like the chatted about in detail in the previous part. But not, the potential logical efficacy from curcumin is bound by the the physicochemical properties regarding worst drinking water solubility and you will instability, which produce reduced bioavailability. Prodrugs away from curcumin give ways to upgrade of biopharmaceutical and you will pharmacokinetic characteristics, and will create exploitation of your own pharmacological results of curcumin. In this chapter, we basic comment brand new physicochemical and you will pharmacokinetics of curcumin. I upcoming explain the appearance of curcumin prodrugs which have increased drinking water solubility and you will increased chemical balances which might be translated to free curcumin upon bioactivation from inside the vivo. We highlight recent profits in this area, having a focus on the structure, synthesis and investigations regarding prodrugs predicated on promoieties also amino acids, essential fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric product including hyaluronic acid and Hint seksi kadД±nlar polyethylene glycol. It part contains the reason behind optimisation of your physicochemical and you may biopharmaceutical features and also the physiological situations out-of curcumin prodrugs, towards the purpose playing with of these curcumin derivatives for the medical software. Read more